If you have been prescribed Depo-Provera, you may be wondering what happens if you take Depo-Provera for more than 2 years. While this contraceptive option can be highly effective, long-term use may lead to some unexpected and concerning side effects. At Lipton Law, based in Southfield, MI, we understand the potential risks associated with prolonged use of Depo-Provera and are here to help you explore your legal options if you’ve been harmed.
If you or a loved one has suffered from undisclosed side effects of Depo-Provera, such as intracranial meningiomas, contact the Michigan Depo-Provera lawsuit lawyers at Lipton Law today. We can help you navigate the process of filing a claim in this ongoing product liability lawsuit, which can be incredibly difficult to traverse alone.
Contact us at (248) 557-1688 to schedule a free initial consultation with a member of our legal team and discuss your options.
What Is Depo-Provera?
Depo-Provera CI (contraceptive injection) is a prescription birth control method taken by injection. It works to prevent pregnancy by preventing ovulation, thickening cervical mucus to block sperm, and thinning the uterine lining to reduce the likelihood of implantation.
This injectable contraceptive is administered intramuscularly, typically in the upper arm or buttocks, once every three months. Normally, the medication is administered within the first five days of a person’s menstrual cycle to ensure they are not pregnant. A pregnancy test may be required before the injection to confirm they are not pregnant at the time of administration.
In addition to being a commonly used long-term birth control option, it is also prescribed for certain medical conditions, such as endometriosis or abnormal uterine bleeding. While effective, its use is associated with potential side effects, including decreased bone density when used for extended periods. Additionally, it is not effective at protecting against sexually transmitted infections.
Active Ingredient: Depot Medroxyprogesterone Acetate
Depo-Provera is a depot medroxyprogesterone acetate injectable suspension. The active ingredient in the injection is medroxyprogesterone acetate, a synthetic form of the hormone progestin. It works by suppressing ovulation, meaning the ovaries do not release an egg each month.
Additionally, it thickens cervical mucus, making it more difficult for sperm to enter the uterus, and it thins the uterine lining, reducing the likelihood of implantation. These combined actions effectively prevent pregnancy.

Why Do People Take Depo-Provera?
People take the Depo-Provera injections primarily for long-term, effective birth control, as it offers protection against pregnancy for three months per injection. It is also prescribed for medical reasons, such as managing symptoms of endometriosis, heavy or painful menstrual bleeding, and reducing the risk of endometrial cancer in certain patients. The convenience of infrequent dosing and its high efficacy rate make it a popular choice for many individuals seeking reliable contraceptive options.
Long-Term Side Effects from the Birth Control Shot
Long-term use of Depo-Provera can lead to various side effects that may affect physical and emotional health. While highly effective as a contraceptive, it’s important to understand the potential risks, including changes in bone density, mood, and overall well-being.
Below are some of the most common side effects associated with using Depo-Provera long-term. If you have experienced any of these side effects after starting Depo-Provera, contact a personal injury attorney in Southfield like the ones at Lipton Law. We can help you explore your options and determine whether or not you are eligible for compensation.
Bone Mineral Density Loss
One significant concern associated with long-term use of the birth control shot is its impact on bone health. Depo-Provera can reduce bone density, which may increase the risk of osteoporosis and fractures over time. This is particularly concerning for younger women whose bones are still developing and have not reached peak bone mass yet. Experts recommend limiting use to no more than two years unless no other contraceptive options are suitable, and patients may benefit from incorporating calcium and vitamin D into their diet to help mitigate this risk.
Delayed Return of Fertility
While the birth control shot is highly effective at preventing pregnancy while actively taking the medication, it may take longer for fertility to return after stopping the injections. For some users, it can take 10 months or more before ovulation and normal menstrual cycles resume. This delay can be frustrating for those who wish to conceive soon after discontinuing the shot, making it an important factor to consider when choosing Depo-Provera as a contraceptive option.
Vision Problems
Some of the more rare side effects of Depo-Provera include vision problems, such as blurred vision or difficulty focusing. These issues may be related to changes in fluid retention or other hormonal effects caused by the injection. While uncommon, any changes in vision should be evaluated by a healthcare provider to rule out serious complications, such as increased intraocular pressure or optic nerve damage.
Blood Clots
While rare, the birth control shot has been linked to an increased risk of developing blood clots, which can lead to serious complications such as deep vein thrombosis or pulmonary embolism. This risk may be higher for individuals with preexisting conditions or other risk factors, such as smoking or obesity. Recognizing symptoms like swelling, pain in the limbs, or sudden shortness of breath is crucial, as early medical intervention can prevent life-threatening outcomes.
Severe Depression
Some users of the birth control shot report experiencing mood changes, including severe depression, over time. The hormonal changes caused by Depo-Provera can affect brain chemistry, leading to symptoms such as persistent sadness, fatigue, or difficulty concentrating. Changes to the body such as weight gain or loss can also affect the user’s mood. If these symptoms arise, it’s important to consult a healthcare provider, as alternative contraceptive options may be better suited for individuals prone to mood disorders.

Intracranial Meningiomas
Prolonged use of Depo-Provera has been associated, in rare cases, with the development of intracranial meningiomas—benign tumors that form on the membranes covering the brain and spinal cord. Though uncommon, this risk appears to increase with long-term, high-dose exposure. Patients experiencing persistent headaches, vision changes, or neurological symptoms should seek medical evaluation to rule out potential complications.
Intracranial meningiomas are some of the most serious long-term side effects associated with this hormonal contraceptive. If you have suffered from a meningioma after starting Depo-Provera, contact an attorney at Lipton Law today to discuss your options moving forward.
Menstrual Irregularities
One of the most common long-term effects of the birth control shot is its impact on the patient’s menstrual cycle. Many users experience irregular bleeding, heavy bleeding, spotting, or even complete cessation of periods over time. While some individuals appreciate the lack of monthly cycles, others may find the unpredictability concerning. These changes occur due to the hormone’s effect on the uterine lining and can persist for months after stopping the injections.
Changes in Liver Function
Long-term use of the birth control shot may affect liver health in some individuals. Depo-Provera can alter liver enzyme levels, which could potentially indicate liver stress or dysfunction. While this side effect is uncommon, individuals with preexisting liver conditions or liver disease should discuss these risks with their healthcare provider. Regular monitoring of liver function tests can help ensure any issues are detected early.
Increased Risk of Developing Certain Cancers
Prolonged exposure to the hormones in Depo-Provera may be linked to an increased risk of certain cancers, such as breast cancer and cervical cancer. Although the risk is relatively low, it is an important consideration for individuals with a family history of cancer or other risk factors. Regular screenings and open communication with a healthcare provider can help users make informed decisions about their contraceptive options.

Does the Depo Shot Cause Brain Cancer?
The Depo shot has been associated with a rare risk of developing intracranial meningiomas, which are typically benign brain tumors. Research suggests this risk may increase with long-term, high-dose use of the medication.
However, it is important to note that these cases are uncommon, and the Depo shot is not generally considered a direct cause of brain cancer. If you have concerns about this risk, discuss your medical history with your healthcare provider and consider other hormonal contraceptives.
Do the Generic Versions of Depo-Provera Cause the Same Side Effects?
Yes, the generic versions of Depo-Provera, which also contain medroxyprogesterone acetate as the active ingredient, can cause the same side effects as the brand-name version. Since both the brand-name and generic options use the same hormonal formulation, they carry similar risks, including changes in bone density, menstrual irregularities, and potential mood changes.
If you experience any of the mild or severe side effects of Depo-Provera or the generic version of the medication, consult with your healthcare provider as soon as possible.
What to Know About Depo Warning Label Changes in Europe and the U.K.
The primary difference between the side effects listed on Depo-Provera warning labels in the US versus the UK and Europe lies in the mention of brain tumors. On the European and U.K. warning labels for Depo-Provera, there are specific warnings about the potential risk of intracranial meningiomas (benign brain tumors) associated with prolonged use of Depo-Provera.
However, this risk is not mentioned on the U.S. warning label for Depo-Provera, despite similar studies linking long-term, high-dose use to meningiomas. This discrepancy may reflect differing regulatory standards and requirements for safety disclosures across regions.
What Side Effects Can Depo Cause After Stopping the Medication?
After stopping Depo-Provera, some individuals may experience side effects related to the body’s adjustment to hormonal changes. These can include delayed return of fertility, irregular periods, or changes in menstrual flow as the body resumes normal ovulation.
Additionally, some users may experience mood swings or depression as hormone levels stabilize. It’s important to give your body time to adjust and consult a healthcare provider if side effects persist or cause concern.
If you plan to continue preventing pregnancy, it’s important to discuss starting other birth control methods after you stop taking Depo-Provera. Once 89 days have passed since your last injection, Depo-Provera is no longer effective at preventing pregnancy.
Can You File a Depo-Provera Lawsuit?
Yes, it is possible to file a Depo-Provera lawsuit if you believe you have experienced significant side effects that were not properly warned about, such as bone density loss, mood disorders, or even rare conditions like brain tumors. If you were not fully informed about the potential risks or suffered harm due to the use of Depo-Provera, you may have grounds for a legal claim.
At Lipton Law, our Michigan defective product lawyers can help you evaluate the merits of your case and guide you through the complex legal process of filing a lawsuit. We will investigate the details of your situation, consult medical experts, and build a strong case on your behalf.
Whether you experienced side effects that led to physical injury, emotional distress, or long-term health complications, we are here to help you seek compensation for medical costs, pain and suffering, and other damages. Our attorneys will provide personalized legal counsel to help you guide you through the legal process and help you seek justice in the face of the damages you’ve suffered from taking the injectable hormonal contraceptive.

Contact a Michigan Depo Attorney at Lipton Law Today
If you or a loved one has experienced harmful side effects from Depo-Provera like brain tumors, it’s important to understand your legal options moving forward. At Lipton Law, our skilled product liability attorneys are dedicated to holding manufacturers accountable for the harm caused by their products.
We have extensive experience helping individuals who have suffered from adverse reactions to medications like Depo-Provera, and we are committed to advocating for your rights. Contact a Michigan Depo-Provera attorney at Lipton Law today to discuss your case.
Call (248) 557-1688 or contact us online to schedule your free consultation with us today.